In women genital organs, different aerobic and anaerobic microorganisms are living in a dynamic balance. Complicated interactions and synergy between vaginal microflora and the host maintain hemostasis in vagina. This dynamic ecosystem is affected by age, pregnancy, Infectious diseases, birth control methods, pharmaceuticals and etc. vaginal flora contains more than 50 types of bacteria, of which, lactic acid bacteria are %95 dominant flora in healthy women. Yeasts like candidia and anaerobic bacteria like gardnerella and mycoplasma are main causes of Bacterial Vaginosis (BV). In this condition the population of lactic acid bacteria decrease and anaerobic gram negative bacteria, gram positive coccus and aerobic pathogens increase. The treatment of these infections are mostly antibiotics that will reduce lactic acid bacteria even more and eliminate normal vaginal flora.
Lactobacillus can maintain vaginal normal microflora by preventing the growth of pathogens and opportunistic bacteria. These microorganisms, can improve the condition by producing antimicrobial compounds, boosting the immune system, destructing biofilms made my fungal (Candida) and bacterial (Gardnerella vaginalis) infections. Hence, using probiotics that contain lactic acid bacteria can improve and maintain women health by improving vaginal microflora.
BioFemVage
BioFemVage
Active substance: Lactobacillus plantarum
Other ingredients: Magnesium stearate, Lactose
Indications
Indications
- Help prevent recurrent vaginal infections.
- Improve general women health
- Cure recurrent bacterial and fungal vaginal infections
- Regulating vaginal microbial flora after antibiotic use
Mechanism of action
Mechanism of action
- boosting immune system
- Ability to connect to vaginal epithelium cells,
- Replacing pathogens by binding to vaginal epithelial cells.
- Decrease vaginal pH by producing organic acids especially lactic acids
- Produce antimicrobial compounds like bacteriocin and hydrogen peroxide
- Destruct biofilm made by pathogenic bacteria
- Maintain normal vaginal flora
- Restoration of normal vaginal flora after taking antibiotics.
How the capsule affects the vagina
How the capsule affects the vagina
One of the most important features of lactobacilli is their ability to attach to vaginal epithelial cells preventing the attachment of pathogens and infection. Also, these bacteria produce organic acids such as lactic acid in the vagina which lower the pH of the vagina and prevent the growth of opportunity seeker pathogenic microorganisms. Lactic acid bacteria can inhibit Gardenella vaginalis by producing hydrogen peroxide.
The use of vaginal probiotic products, that is used directly, causes faster results. This product is a suitable vaginal capsule that causes probiotic bacteria to be transferred directly to the source of the infection. Lactobacilli help prevent recurrent vaginal infections by restoring the natural environment of the vagina and creating a protective layer on the vaginal wall. In addition, this product is able to restore the natural flora of the vagina after taking antibiotics.
side effects
side effects
So far, no specific side effects have been reported for this product.
Precautions
Precautions
In case of cardiac problems, endocarditis and immune deficiency or in case of organ transplant using probiotic should be under doctor supervision.
Consumption in special groups
Consumption in special groups
Pregnant women, people who want to become pregnant and women who are breastfeeding should consult their doctor before use. People with allergies should consult their doctor before use.
drug interactions
drug interactions
- No drug interactions.
- During the use of vaginal antibiotic creams or suppositories, vaginal probiotic capsules should be used at least 2 hours after taking antibiotics.
Storage
Storage
Keep in cool and dry places with temperature of 25 °C
The results of clinical studies on Lactobacillus plantarum strains
The results of clinical studies on Lactobacillus plantarum strains
Antonio Cianci et el.(2008) investigated the effect of vaginal capsules containing Lactobacillus plantarum in preventing vaginal infections in women prone to bacterial vaginosis or with a history of recurrent vaginal infections in a cohort study. In this study, the risk of vaginal infections in women who were not treated with Lactobacillus plantarum showed to be much higher on 4 months after entering the study. And this strain can reduce the risk of recurring vaginal infections in people prone to the disease (1).
De Seta et el. (2014) investigated 89 women with vulvaginitis candidiasis in a retrospective study. In this study, Lactobacillus plantarum vaginal suppositories were used following the routine treatment of candidiasis in the probiotic group. At the end of this study, the amount of lactic acid bacteria was significantly increased in women receiving probiotics compared to the control group. Also, a significant reduction was observed in symptoms such as itching and burning in these women (2).
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