Prebiotics are a group of nutrients usually belonging to carbohydrates (such as inulin) family that, if consumed orally, lead to growth and nutrition of beneficial bacteria in the gastrointestinal tract and their relationship with human health has received much attention in recent years. Prebiotics are naturally found in certain fruits, vegetables, and plants, including artichoke, asparagus, bananas, chicory, garlic, and onions. Prebiotics are almost or absolutely indigestible to human gastrointestinal enzymes, but are selectively broken and converted to short-chain fatty acids by at least one probiotic bacterium in the intestine through the process of fermentation and can lead to improved host health by stimulating the growth or activity of one or more Clone bacteria.
The International Scientific Association of Probiotics and Prebiotics (ISAPP) defined prebiotics as fermentable selective material bringing about specific changes in the composition or activity of the gastrointestinal microflora and offers benefits to the host’s health.
According to the WHO, the probiotics are living microorganisms that have health effects if consumed in sufficient quantities.
Nowadays, the tendency to consume prebiotics and probiotics to advance human digestive health has augmented. Consumption of beneficial probiotic bacteria together with oligosaccharides promotes the bacterial composition of clone leads to improved general health. Countless studies indicate that the microbial population of the intestine consists of many species of bacteria, including pathogens and beneficial bacteria, which are responsible for human intestinal health. When the beneficial bacteria in the intestine decreases, the microbial balance is disturbed and the pathogenic bacteria cause health problems.
Synbiotic are referred to products which are a combination of probiotics and prebiotics. In synbiotic products, prebiotics (such as inulin) are used to stabilize and stimulate the growth of beneficial living microorganisms (probiotics) within the product. In fact, using prebiotics will be absolutely helpful to overcome the possible survival problems that probiotic bacteria face when passing through the upper intestinal tract; Using synbiotic products is one of the best ways to restore the balance and maintain a positive intestinal condition.
Active substance: Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus plantarum, Streptococcus thermophilus, Bifidobacterium longum and Inulin
Dosage: 1×109 CFU/Sachet
• Maintain and strengthen the intestinal normal flora.
• Improves gastrointestinal function and prevents constipation
• Improvement of fatty liver disease (Non-alcoholic fatty liver disease (NAFLD) and Nonalcoholic steatohepatitis (NASH))
• Helps control blood cholesterol and triglyceride levels
• Helps control blood sugar
• Reduce the risk of high blood pressure
• Reduces the risk of osteoporosis
Take 3 sachets daily after meal with your meal or as prescribed
Mechanisms of action
• Enhancing the gastrointestinal health by striking the right balance between beneficial and harmful bacteria and stimulating the growth of beneficial bacteria.
• Stimulating the clone smoky movements through prebiotic fermentation, consequently improving constipation and abdominal pain and increasing defecation frequency.
• Facilitating calcium absorption through inulin and improving bone’s mineral density and reducing the risk of osteoporosis.
• Facilitating the reduction of high levels of triglycerides in blood and liver.
• Facilitating the control of blood sugar in diabetes and pre-diabetes patients by decreasing the glycemic index response to sucrose and maltose due to reduced activity of disaccharide enzymes in the gastrointestinal tract.
• Facilitating weight lose by reducing total daily calorie intake, due to less calories compared to other digestible carbohydrates.
• Decreasing the risk of hypertension by producing short-chain fatty acids through fermentation of prebiotics by bacteria, leading to a reduction in fats and cholesterol.
• Enhancing the absorption of ions such as iron, magnesium, calcium and zinc by absorbing lactate in the large intestine and subsequently improving the immune system and human digestive health.
In some cases, using this product may lead to bloat and gas in gastro intestinal tract at the beginning but it will disappear after a while. Consult with your physician if any other side effects are observed.
There is no contraindication for this product. In case of cardiac problems, endocarditis and immune deficiency consult your doctor before use. In case of abdominal surgery, short bowel syndrome surgery or organ transplant using probiotic should be under doctor supervision.
Using in special groups
Consult your doctor before taking this product during pregnancy or breastfeeding.
Use with caution with immunosuppressive drugs.
Keep for 2 years in cool and dry places with temperature of 25 °C
Results of clinical studies regarding the use of probiotics and prebiotics
Synbiotics are products containing a combination of probiotics and prebiotics which enhance the beneficial intestinal population through their interaction with each. The term “Synbiotics” is used when prebiotics positively affect the development of certain probiotics. Lactobacillus and Bifidobacterium-inulin are examples of this combination. Synbiotics function in two ways:
1. Improving the survival of probiotics
2. Fostering special health benefits.
Findings of in vitro and human published studies indicated that inulin can stimulate the growth or activity of beneficial bacteria in the large intestine; this stimulation can enhance the intestinal flora’s composition, boost the immune system, and consequently improve the host health. Studies indicate that consumption of inulin can significantly lessen the number of pathogenic bacteria and increase the number of beneficial bacteria.
The potential of prebiotics can be assessed by fermentability of compounds based on the indigenous population of Bifidobacterium and Lactobacilli in the clone; the function of inulin in this regard has been extensively confirmed by numerous studies. Analyzing the changes in intestinal population composition, microbial balance and production of short-chain fatty acids (propionate, butyrate, acetate) in the colon is among the important factors used to evaluate the potential of prebiotics and their effect.
The findings of Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Test for inulin indicated that the population of Bifidobacteria as well as the production of propionate and butyrate increased significantly in the intestine.
Analysis of feces of a group of mice fed inulin, soy oligosaccharide, and Fructooligosaccharides together with Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium lactis probiotic bacteria indicated that inulin increased the storage and survival time during the consumption of these three types of probiotics.
The effect of inulin with the Lactobacillus rhamnosus and Bifidobacterium lactis probiotics on intestinal immune function in mice was analyzed in another study. The findings indicated that although inulin alone induces intestinal immunity, its consumption with these two probiotics is significantly more effective.
Another study delved into 71 children with irritable bowel syndrome. The findings indicated that the consumption of Lactobacillus plantarum, Lactobacillus rhamnosus and Bifidobacterium lactis probiotics at 5×109 dose with 900 mg of inulin for four weeks significantly improved constipation symptoms.
Furthermore, a study on 1039 adolescents showed that probiotics have a significant impact on various factors associated with diabetes complications and reduce obesity, reduce body mass index (BMI) and decrease the waist-to-hip ratio (WHR). Probiotics also regulate blood pressure, HDL cholesterol and triglycerides and significantly improve blood sugar control.
Children and adolescents between 8 and 17 years were investigated. It was found that the inulin probiotic was a potent factor in the treatment of type 1 diabetes. It functions by reducing endotoxemia, reducing insulin resistance, improving blood sugar control, changing the microbiota and permeability of intestinal epithelial cells by creating severe hypoglycemia.