Countless investigations have recommended probiotics as an adjunct therapy to treat acute diarrhea. The term “probiotic” is originally a Greek word meaning “for life”.
Various definitions were later offered until when Fuller redefined probiotics in 1985: “A live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance”. The World Health Organization (WHO) introduced probiotics as living microorganisms that have beneficial effects on host health if consumed in sufficient quantities.
Nowadays, probiotics are used in different fields of prevention and treatment, particularly in acute infectious diarrhea. The findings of a systematic review of 56 studies regarding infants and children indicated that probiotics are safe and significant reduce the period and frequency of acute infectious diarrhea.
ORS (Oral Rehydration Salt) is the recommended treatment for diarrhea proposed by the World Health Organization, which has been proved to reduce the mortality of this disease and can be extremely useful in combination with probiotics.
Active substance: Lactobacillus reuteri, Zinc gluconate, Vitamin A (5000 IU/Sachet), ORS (potassium chloride, sodium citrate, sodium chloride & glucose)
Other ingredients: Orang Flavor
Dosage: 2.5×108 CFU/Sachet
• Helps for treating acute and persistent diarrhea
• Mild to moderate dehydration treatment by oral rehydration therapy (ORT)
• Shorten the duration and severity of diarrheal episodes
• Modulation and regulation of immune responses
Administer 1-4 sachets daily based on a child’s weight, age and severity of diarrhea (according to the doctor’s instructions), until the symptoms subsided.
• Stir 1 sachet into 250 ml of cooled boiled water
• Consumed within 6 hours when stored in refrigerator (max 4 °C/39 °F) and within 3 hours when stored in room temperature (max 25 °C/77 °F)
Mechanisms of action
• PROBIOTIC (Lactobacillus reuteri):
1- Restores intestinal flora and supports digestive health
2- Protective role against gastro-intestinal pathogens
3- Reduces the duration and the severity of diarrhea in children both bacterial and viral origin
4- Improves mucosal immunity (mucus secretion and IgA production)
• Oral Rehydration Salt (ORS):
1- Replaces fluid and electrolytes through oral hydration
1- Recommended by WHO for treatment of diarrhea in children
2- Shorten the duration and severity of diarrheal episodes by regeneration of gut epithelium and mucosal integrity
3- Improves intestinal absorption of water and electrolytes
4- Enhanced immune response and early clearance of pathogens from the intestine
• Vitamin A:
1- Recommended by WHO for treatment of diarrhea in children
2- Prevents prolonged diarrhea by early repair of the intestinal cells, mucosa and barriers to infection
All probiotics are parts of natural human digestive microflora. They are all registered as safe and GRASS products by FDA without any side effects or toxicity reports. In some cases, using this product may lead to bloat and gas in gastro intestinal tract at the beginning but it will disappear after a while. Consult with your physician if any other side effects are observed.
There is no contraindication for this product. In case of immune deficiency consult your doctor before use. In case of abdominal surgery, short bowel syndrome surgery or risk of mesenteric ischemia using probiotic should be used with caution.
Use with caution in children that use immunosuppressive drugs.
Keep in cool and dry places in room temperature (25 °C). Avoid direct sun light.
keep away from children.
Clinical trials on lactobacillus reuteri
• Evaluation of the effect of ORS with probiotics, zinc and vitamin A on diarrhea in children, a double-blind clinical trial
In one study, children aged 9 months to 5 years old with complaints of acute watery diarrhea were studied. Children were randomly divided into five groups. Patients in group 1- zinc gluconate, with ORS, group 2- vitamin A with ORS, group 3- probiotic with ORS, group 4- zinc gluconate, vitamin A and probiotic with ORS and group 5- ORS alone were treated with 1-4 sachets daily based on a child’s weight, age and severity of diarrhea. The statistical analysis of results showed that children receiving zinc supplementation (5 mg/sachet), vitamin A (5000 IU/Sachet), probiotic (2.5×108 CFU/Sachet) and ORS had significantly reduced the number and duration of diarrhea and duration of hospitalization.
A study conducted on identical and comparable groups in terms of demographic features including gender, age, and weight and clinical features such as the duration and frequency of diarrhea illustrated that the duration of diarrhea decreased in the combined group (probiotics and ORS) compared to the ORS group lacking probiotics. The frequency of diarrhea decreased after consumption in all groups compared to pre-consumption status.
In these investigations, the probiotics and ORS combination indicated the greatest decrease in terms of duration of diarrhea, frequency of diarrhea and duration of hospitalization.
Medications to treat diarrhea affect bowel movements, transport of ion and intestinal bacteria to reduce the length of diarrhea. Probiotics have significantly promoted their position in the treatment of diarrhea. However, microorganisms are still considered more frequently as a food additive than a medication in most countries. Therefore, studying the safety and harmlessness aspects of probiotics has taken precedence over their clinical efficacy in the food industry research.
Vitamin A and zinc are among other beneficial supplements in this product, which could be a response to malnutrition in children with these two nutrients in addition to possessing therapeutic effects, as reported by many studies.
Studies have indicated that zinc, vitamin A, probiotic and ORS supplements had a positive effect on reducing the number and duration of diarrhea in children.