Probiotics are live microorganisms that have positive effects by balancing microbial population in body. These positive effects are different in regards to on type of microorganisms, dose, duration of use and method of use. Probiotics alter metabolic conditions like diabetes in body by affecting digestive microbiota. They improve the host metabolism. So, these days they are highly recommended for regulating and modulating microbiota and metabolic activities.


Active substance: Bacillus coagulans, Lactobacillus acidophilus, Bifidobacterium lactis, lactobacillus casei, bifidobacterium longum,  Bifidobacterium bifidum.
Other ingredients: Magnesium stearate, Maltodextrin
Dosage: 3×109 CFU/Capsule

Why use

• Control blood sugar
• Regulating metabolism
• Decrease oxidative stress damages
• Improve HbA1c and fasting insulin level (blood sugar control factors)
• Decrease resistance to insulin (HOMA-IR)
• Balance immune system

Recommended use

Take 1-2 capsules daily or as prescribed.

BioDiab advantages over same products

This product is dried in vacuum freeze drier without any heat. This leads to better survivability and preservation of all bacteria characteristics and abilities. The strain used in product have inspiring effect in patients with diabetes mellitus type 2.

Mechanisms of action

• Increase number of lactic acid bacteria and decrease bacteroides in intestine.
• Improve innate immune response
• Decrease proinflammatory and inflammatory cytokines gene transcription and increase immunity modulator cytokines production like IL-10 and improve mild inflammation in diabetic patients
• Process Bile salt hydrolase (BSH) enzyme which increase primary bile salt that activates farnesoid x receptor that will increase glucose saving and decrease glucose production from non-sugar sources and elevates insulin synthesis and secretion consequently.
• Increase GLP- 1 and GLP- 2(glucagon like peptides) that decrease mild inflammation in diabetic patients and reduce resistance to insulin that consequently lower beta pancreas cell toxicity and balance blood sugar.
• Producing short chain fatty acids like butyrate by probiotics such as Bifidobacteria causes differentiation, duplication and evolution of beta pancreas cell and insulin resistance reduction, increase in GLP-1 secretion that leads to increased insulin secretin and decrease secretion of proinflammatory cytokines by adipose tissue.
• Change intestine microbiota and reduce intestine mucus permeability that inhibits transmission of bacterial lipopolysaccharides from intestine lumen to other organs.
• Induce adipocyte differentiation to insulin sensitive cells.
• Decrease phagocyte activity in adipose tissue
• Decrease stress gene expression in skeletal muscle that leads to lower lipotoxicity
• Increase glucan like peptides (GLP-1) production by enteroendocrine cells that leads to better carbohydrate metabolism, lower glucotoxicity and increase sensitivity to insulin in target cells.
• Increase insulin secretion from beta pancreas cells
• Increase short chain fatty acids like butyric acid in colon that increase lactobacillus and Bifidobacteria and GLP-1 secretin
• Decrease alpha amylase serum activity and restrict hydrolyze process and carbohydrate absorption
• Decrease visceral fat
• Inhibit lipid peroxidation and maintain antioxidant enzyme activity like superoxide dismutase and catalase
• Stimulate tool like receptors (TLRs) by immune modulating activity and inhibit inflammatory cytokine production and change TGF-β
• Decrease glucose by consuming it as food
• Inhibit free radicals like nitric oxide production and destructing pancreas beta cells.
• Increase superoxide dismutase and glutathione peroxidase in red blood cells that leads to better antioxidant status

Side effects

in some cases, using this product may lead to bloat and gas in gastro intestinal tract at the beginning but it will disappear after a while. Consult with your physician if any other side effects are observed.


There is no contraindication for this case of cardiac problems, endocarditis and immune deficiency consult your doctor before use .in case of abdominal surgery, short bowel syndrome surgery or organ transplant using probiotic should be under doctor supervision.

Using in special groups

Consult your doctor before taking BioDiab during pregnancy or breastfeeding.

Drug interaction

Use with caution with immunosuppressive drugs.


Keep for 2 years in cool and dry places with temperature of 25 °C

Clinical trials

In a clinical trial that was done by Firouzi et al on 136 patients with diabetes type 2, Probiotic with lactobacillus acidophilus, lactobacillus lactis, lactobacillus casei, bifidobacterium longum, bifidobacterium bifidum, and bifidobacterium infantis strains, was administered for 12 weeks and the results showed significant decrease in fasting insulin, insulin resistance (HOMA-IR) and HbA1c In a trial done on patients with pregnancy diabetes, lactobacillus acidophilus, lactobacillus casei, and bifidobacterium bifidum were administered for 6 weeks. The results showed positive effects on fasting blood sugar control, insulin level in serum, hemostasis factors HOMA-IR (insulin resistance) and HOMA –β (pancreas β cell function). significant decrease in triglycerides and VLDL in patients’ blood were observed (Karamali et al).
Clinical trials done by Taghizadeh et al showed that using probiotic containing bacillus coagulans for 9 months in pregnant women significantly decrease serum insulin and increase quantitative insulin sensitivity check index.
In another investigation it was concluded that consuming synbiotic bread that contained bacillus coagulans for 8 weeks significantly decreased serum insulin level by affecting insulin metabolism in diabetic patients (Tajabadi Ebrahimi, M et al).
Also, in a study conducted on 70-35, 62-year-old diabetic patients, it was shown that consuming food that contained bacillus coagulans for 6 weeks had significantly decrease serum insulin level and hs-CRP and increased glutathione plasma level and uric acid (Asemi et al).

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