Probiotics are products containing live microorganisms that, “when administered in adequate amounts, confer a health benefit on the host and balance
microflora”. Yeasts are about %0.1 of intestinal microflora.
Yeasts have a vital role in human health, probiotics have different functions of action including:
• Prevention and treatment of diarrhea caused by antibiotics, viral and bacterial diarrhea (specially Clostridium difficile), Travelers’ diarrhea and diarrhea caused by feeding through feeding tube.
• Prevention and healing of gastrointestinal ulcers resulting from Helicobacter pylori infections.
• Improving immune system and resistance to infectious diseases.
• Improve digestion and food absorption
• Decrease chance of diarrhea and gastro-intestinal inflammations
• Producing antimicrobial agents like bacteriocin, organic fatty acids, hydrogen peroxide …


Active substance: Saccharomyces boulardii
Other ingredients: Magnesium stearate, Lactose
Dosage: 5×109 CFU/Sachet

Why use

• Improving symptoms of helicobacter pylori and prevention and treatment of gastric and duodenal ulcers
• Prevention and treatment of diarrhea caused by antibiotics, viral and bacterial diarrhea (specially Clostridium difficile), Travelers’ diarrhea and diarrhea caused by feeding through feeding tube.
• Used as adjuvant for diarrhea treatment and diarrhea caused by antibiotic administration
• Improving intestinal microbiota pattern

Recommended use

Take 1-2 sachets daily with your meal or as prescribed.

Mechanisms of action

• Reducing antibiotic side effects used for helicobacter pylori treatment
• Detoxification of pathogenic intestinal toxins
• Competing with pathogens for adhesion to intestinal mucus
• Suppressing the expression of host surface receptors expression that leads to less pathogen attachment to intestine surface
• Boosting and modulating systemic and local (intestine wall) immune responses
• Inhibiting the production of nitrous oxide
• Stimulating production of proinflammatory molecules in colon cell like: PPAR (PEROXISOME PROLIFRATOR ACTIVATED RECEPROR GAMMA)
• Increasing antibiotic resistance in prokaryotes that repair intestine microflora after antibiotic Treatment
• Stimulating production of antibody against Clostridium difficile
• Inhibiting short chain myosin phosphorylation that controls tight junction permeability in intestines and reduces pathogen entrance and transmission
• Phosphatase production and dephosphorylation of pathogen bacteria endotoxins like E.coli 055:B5
• Altering intracellular signaling of proinflammatory cytokine production
• Increasing IgA expression in mucosal tissue that improves innate immunity
• Neutralizing virulence of pathogen bacteria factors
• Stimulating growth and differentiation of intestinal cells in response to trophic factors
• Increasing enzyme release in brush border membrane

Side effects

in some cases, using this product may lead to bloat and gas in gastro intestinal tract at the beginning but it will disappear after a while. consult with your physician if any other side effects are observed.


There is no contraindication for this product. In case of cardiac problems, endocarditis and immune deficiency consult your doctor before use. In case of abdominal surgery. Short bowel syndrome surgery or organ transplant using probiotic should be under doctor supervision.

Using in special groups

Consult your doctor before taking BioDigest during pregnancy or breastfeeding.

Drug interaction

Use with caution with immunosuppressive drugs.


Keep for 2 years in cool and dry places with temperature of 25 °C

Clinical trial on Saccharomyces boulardii

Helicobacter pylori treatment:
Researches have shown that administrating saccharomyces boulardii in patient that are using antibiotic for helicobacter pylori will accelerate the treatment and decrease treatment side effects like diarrhea (szajewska,H .et al)
Also, in a research done by Cindourk, M. et al, it was shown that saccharomyces boulardii could improve diarrhea, digestive problems and antibiotic tolerance in helicobacter pylori addition this yeast could improve indigestion caused by antibiotic treatments.
Also in an investigation done by Hurduc,V et al .it was proven that side effects of antibiotic treatment of helicobacter pylori in children were decreased by using saccharomyces boulardii.
Anti-inflammatory effects in intestines:
These yeasts can be helpful in treatment of intestine inflammatory diseases. The research has shown that saccharomyces boulardii can be effective in improving the symptoms of Crohn’s disease. Also, it was proven that saccharomyces boulardii is effective in treatment of ulcerative colitis (Guslandi, al).
Irritable Bowel Syndrome:
studies have shown that saccharomyces boulardii is effective in improving the symptoms of IBS (Choi, C.H .et al).
Detoxification effect:
Saccharomyces boulardii detoxifies intestinal pathogens toxins by various mechanisms. the most important mechanisms are blocking cellular receptors (Castagliulo, I et al) and pathogen receptors entrapment. (Kelesidi,T et al)
Function in intestinal mucus:
Saccharomyces boulardii is an activator for effective enzymes and nutritional factors in intestines. In addition this yeast improves the defense system and nutritional absorption (Buts, J.P et al).
Improving the immune system:
The researches have shown that saccharomyces boulardii inhibits the adhesion of candida albicans to gastrointestinal epithelial cells significantly.
Hence it is effective on common infections like candida albicans, and pathogens that cause immune deficiency. In addition, this yeast can decrease inflammatory response caused by candida albicans (Murzyn,A et al).

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