Probiotics are products containing live microorganisms that, “when administered in adequate amounts, confer a health benefit on the host and balance microflora”. Researches have proven that probiotics are effective in treatment and prevention of infectious diarrhea, antibiotic induced diarrhea, necrotic enterocolitis, allergy, helicobacter pylori infection and infant colitis.
Active substance: Lactobacillus reuteri
Other ingredients: MCT oil, Sunflower oil and Aerosil
Dosage: 1×109 CFU/ml
• Improve infant colitis
• Decrease regurgitation and reflux in infants
• Improve functional constipation in infants
• Decrease crying periods in infants
• Improve gut and intestine movement in infants and help with intestine gas discharge
• Improve bloat and colitis in infants
• Improve digestion problems, constipation and diarrhea
• Modulating immune system and increase resistance to infectious diseases and seasonal influenza
• Improve infant allergies
Take 5-15 drops daily or as prescribed.
Shake well before use so that the probiotic phase mixes with the oil phase. In order to protect the probiotic bacteria do not add drops to food or warm drinks. prevent contact of the dropper with saliva.
Mechanisms of action
• Lactobacillus reuteri can affect dendritic cells helper type 1 and 2 and balance cytokine production in intestine epithelial cells. (Increase Treg expression and decrease Th17 that increases Treg/Th17 ratio that lowers intestine inflammation and visceral pain).
• Improve gas production and gas discharge in infants by decreasing gas producer pathogen bacteria and improving intestine movements.
• Lactobacillus reuteri can decrease visceral pain by affecting intestinal nerve directly and modulating immune system inflammatory pathways like Mast cells.
• L.reuteri has anti-inflammatory effects with interfering in infants’ intestinal movements by modulating immune responses.
• One of the antimicrobial factors made by l.reuteri is reuterin that has no peptide or compound proteins and is produced during glycerol fermentation. In fact, reuterin is beta-hydroxypropionaldehyde 3 – HPA derived from glycerol in anerobic conditions and has wide functional effect against gram positive and negative bacteria.it can even affect fungi, yeasts and protozoa.
All probiotics are parts of natural human digestive microflora. They are all registered as safe and GRASS products by FDA without any side effects or toxicity reports. In some cases, using this product may lead to bloat and gas in gastro intestinal tract at the beginning but it will disappear after a while. Consult with your physician if any other side effects are observed.
There is no contraindication for this product.in case of immune deficiency consult your doctor before use .in case of abdominal surgery, short bowel syndrome surgery or risk of mesenteric ischemia using probiotic should be used with caution.
Use with caution in children that use immunosuppressive drugs.
• Store in cool and dry places at room temperature. Keep away from moisture, direct sunlight and out of reach of children
Clinical trials on lactobacillus reuteri
In a study that was done by Savino, the differences between healthy infants intestinal microflora and infants with colitis were investigated. Investigations has shown that microflora in infants with colitis has less lactic acid bacteria and more anaerobic gram negative bacteria in comparison to non-colic infants. So increasing the lactic acid bacteria in infants with colic will improve the condition. There is complicated relation between immune system and intestinal flora .in animal studies, intestinal cytokines can cause over reaction in neuromuscular system by neuro-immune and masculo-immune reactions.
Chassard et al recent studies have proven that balancing intestinal microflora with lactobacillus reuteri can decrease risk of intestinal infections and allergic diseases by improving microflora. Lactobacillus reuteri colonization in intestine inhibits pathogen. Lactobacillus reuteri antimicrobial activity in the most important factor in prevention and treatment of infections.
Surawicz and Huebner have shown probiotic capability in preventing and treatment of intestinal infections. Cleusix et al have proven that lactobacillus reuteri can inhibit pathogen growth and activity by producing reuterin.
In a study by M.Urbanska, it was concluded that administrating lactobacillus reuteri in infants is safe and it is very important in infants and children health and can improve colitis symptoms, decrease daily crying periods in infants, solve functional digestive problems like constipation and abdominal pain and decrease regurgitation episodes.
In addition in a study done by P.Coccorullo et al on 6-24 month old infants with constipation it was proven that lactobacillus reuteri has positive effects on constipation management in infants. In another study done by Francesco Savino et al on simethicone and lactobacillus reuteri effects on infants with milk induced colitis, the crying period in infants was reduced from 159 minutes to 51 minutes in lactobacillus reuteri and 177 minutes to 145 minutes in simethicone cases that show significant effect of lactobacillus reuteri after 28 days in reducing colic pains and crying periods.