The Role of Probiotics in Brain and Mental Health:
Neurodegenerative disorders and mental health conditions are a group of ailments closely linked to an imbalance in the gut microbial flora. The degeneration of neurons in the brain and spinal cord, eventually leading to loss of function in affected areas in neurodegenerative diseases, and the imbalance in neurotransmitters in psychosomatic disorders are all associated with dysbiosis of the gut microbial reservoir. According to recent studies, a deficiency or imbalance in the gut microbiota can directly lead to neurological disorders through the Gut-Brain Axis. It has been established that the inflammatory process and oxidative stress can be modulated by correcting the gut microbiota with the help of probiotics. Studies suggest that probiotics can be an effective, economical, and side-effect-free adjunctive therapy.

Active Ingredients: Bacillus coagulans, Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus reuteri, Lactobacillus rhamnosus, and Bifidobacterium longum

Excipients: Vitamin D3 (400 IU), Magnesium stearate, maltodextrin

• Helps reduce systemic inflammation in autoimmune diseases
• Helps improve the symptoms of neurodegenerative diseases
• Helps improve the symptoms of psychosomatic disorders
• Helps improve gastrointestinal problems resulting from underlying diseases
• Provides daily vitamin D needs

• As directed by a physician, take one capsule daily for the first week, then two capsules daily, one hour before lunch or dinner.
• For individuals who have difficulty swallowing capsules, the contents can be dissolved in any non-hot liquid or yogurt and consumed within 10 minutes.

Children 4 years and older and adults.

• Increases beneficial bacteria and balances the microbial flora.
• Increases the level of short-chain fatty acids (SCFAs) and enhances the expression of tight junctions, strengthening the gut barrier.
• Reduces the permeability of the gut barrier and decreases the passage of inflammatory compounds such as lipopolysaccharide (LPS) and other bacterial toxins.
• Prevents the entry of inflammatory compounds into the systemic bloodstream, reducing neuronal damage and strengthening the blood-brain barrier (BBB).
• Reduces the transmission of inflammatory immune system responses to the brain.
• Decreases the secretion of inflammatory cytokines such as TNF-α and increases Treg, modulating the immune system.
• Increases or facilitates the production of amino acid precursors of neurotransmitters, such as tryptophan (precursor of serotonin), tyrosine (precursor of dopamine), and glutamate (precursor of gamma-aminobutyric acid (GABA)), which helps compensate for the reduction of neurotransmitters associated with nervous system diseases.
• Increases antioxidant capacity by increasing glutathione and glutathione peroxidase (GSH, GPx), reducing oxidative stress and lipid peroxidation, and nerve damage.
• Improves cognitive problems following an increase in brain-derived neurotrophic factor (BDNF).
• Improves brain function through the production of vitamins B1, B6, and B12, which play an important role in the synthesis of nucleic acids and amino acid precursors.
• Increases GLP-1 expression and prevents apoptosis of nerve cells.
• Affects the hypothalamus-pituitary-adrenal (HPA) axis and regulates cortisol secretion and suppresses inflammation.
• Modulates the serotonergic system and stimulates signaling to the vagus nerve, DMV, improving mood and reducing symptoms of depression and anxiety.
• Reduces damage to dopaminergic cells and decreases the abnormal accumulation of α-synuclein fibrils in Parkinson’s patients and reduces the accumulation of Amyloid β protein in Alzheimer’s patients.
• Improves anxiety, depressive symptoms, and behavioral problems in some psychosomatic disorders such as autism, bipolar disorder, or borderline personality disorder by modulating the production of serotonin and GABA.
• Improves gastrointestinal problems resulting from neurological diseases such as MS, Parkinson’s, or autism.
• The production of short-chain fatty acids and B vitamins increases ATP production and helps reduce fatigue in patients. Also, short-chain fatty acids like acetate, after entering the systemic bloodstream, are metabolized by muscles and used to enhance skeletal muscle function and can also provide a percentage of the body’s daily calorie needs.

Probiotic microorganisms naturally exist within the body and are deemed safe under GRAS and QPS standards. No significant side effects or toxicity have been reported. In rare cases, probiotics may cause bloating or increased gas production in the digestive tract. These effects typically subside with continued use. Consult a physician or pharmacist if other symptoms arise.

• In cases of pancreatitis, immunodeficiency, immunosuppressant use, venous catheters, recent abdominal surgery, gastrointestinal bleeding, short bowel syndrome, or mesenteric ischemia risk, probiotics should be used with heightened caution and under medical supervision.
• Probiotics can be safely used during pregnancy after the second trimester and during breastfeeding, with a doctor’s approval.

Consult your doctor before taking this product during pregnancy or breastfeeding.

No significant interactions with other drugs have been reported. Maintain a 2 to 6-hour gap when taking antibiotics.

Store in a dry, cool place, away from direct sunlight, at a temperature not exceeding 25°C.

A clinical study on the effect of BioZen D® on Parkinson’s patients showed that 12 weeks of consumption of this supplement could significantly reduce the inflammatory cytokines IL-1β, INF-γ, IL-6, and malondialdehyde, and significantly increase IL-10 and total antioxidant capacity (TAC). Significant reduction in disease severity, anxiety, and relief of gastrointestinal problems were other benefits of BioZen D® consumption in these patients.
A clinical study on the effect of BioZen D® on schizophrenic patients showed that 12 weeks of consumption of this supplement could improve their cognitive function; such that the Montreal Cognitive Assessment (MoCA) score significantly increased in the intervention group.
Evidence from clinical studies on the effect of probiotics on MS patients indicates a reduction in inflammatory cytokines and an increase in anti-inflammatory cytokines. In addition, following probiotic consumption in these patients, improvements in anxiety and depression (BDI, DASS), fatigue (FSS), pain level (PRI), general health (GHQ-28), and Expanded Disability Status Scale (EDSS) have been observed. Reduction in malondialdehyde (MDA), nitric oxide (NO), and hs-CRP were also significant changes following the consumption of probiotic supplements in MS patients. Improved glucose and lipid metabolism is another benefit of probiotics for this group of patients.
Meta-analyses on the effect of probiotics on Alzheimer’s patients and mild cognitive impairment (MCI) indicate improvement in their cognitive function, improvement in daily living skills, reduction in anxiety, and reduction in inflammatory and oxidative stress biomarkers.
The results of meta-analyses on the effect of probiotics on Parkinson’s patients, in addition to improving their gastrointestinal disorders, indicate a reduction in inflammatory cytokines (TNF-α, IL-6), reduction in oxidative stress and increased glutathione levels, reduced neurodegeneration, reduced memory impairment, and increased motor function.
The results of meta-analyses on the effect of probiotics on autistic patients indicate a significant impact on improving behavioral symptoms, adaptability, improving neurotransmitter levels, and improving gastrointestinal problems in them. Improvement in the symptoms of ADHD patients has also been observed with the consumption of probiotic supplements.
In the field of psychosomatic disorders, the results of meta-analyses on the effect of probiotics on schizophrenic patients indicate a reduction in the symptoms of these patients. On the other hand, a clinical study showed that probiotic consumption alongside SSRIs could significantly improve the condition of patients with major depressive disorder (MDD). Other studies on anxiety and stress have also had similar results.
In most diseases of the central nervous system and psychosomatic disorders, the incidence of gastrointestinal problems is high, and the consumption of probiotic supplements has been effective in improving the symptoms of this category of gastrointestinal disorders.
Also, systemic inflammation resulting from dysbiosis of the gut microbial flora in these patients is reduced by the consumption of probiotics. Clinical study results indicate a reduction in inflammatory cytokines in the concurrent use of probiotic supplements and the main treatment.